[New cold-adapted donor strains for live influenza vaccine].
Identifieur interne : 002E00 ( Main/Exploration ); précédent : 002D99; suivant : 002E01[New cold-adapted donor strains for live influenza vaccine].
Auteurs : Iu Z. Gendon ; S G Markushin ; T M Tsfasman ; I I Akopova ; N K Akhmatova ; I B KoptiaevaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adaptation physiologique (génétique), Animaux, Basse température, Chiens, Embryon de poulet, Humains, Lignée cellulaire, Mutation, Souris, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (métabolisme), Substitution d'acide aminé, Vaccins antigrippaux (biosynthèse), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (biosynthèse), Vaccins atténués (génétique), Vaccins atténués (immunologie).
- MESH :
- biosynthèse : Vaccins antigrippaux, Vaccins atténués.
- génétique : Adaptation physiologique, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués.
- immunologie : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués.
- métabolisme : Sous-type H2N2 du virus de la grippe A.
- Animaux, Basse température, Chiens, Embryon de poulet, Humains, Lignée cellulaire, Mutation, Souris, Substitution d'acide aminé.
English descriptors
- KwdEn :
- Adaptation, Physiological (genetics), Amino Acid Substitution, Animals, Cell Line, Chick Embryo, Cold Temperature, Dogs, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H2N2 Subtype (metabolism), Influenza Vaccines (biosynthesis), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Mutation, Vaccines, Attenuated (biosynthesis), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology).
- MESH :
- chemical , biosynthesis : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Adaptation, Physiological, Influenza A Virus, H2N2 Subtype, Influenza Vaccines, Vaccines, Attenuated.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza Vaccines, Vaccines, Attenuated.
- metabolism : Influenza A Virus, H2N2 Subtype.
- Amino Acid Substitution, Animals, Cell Line, Chick Embryo, Cold Temperature, Dogs, Humans, Mice, Mutation.
Abstract
Cold-adapted (CA) strains A/Krasnodar/35 and B/Victoria/63 were isolated using passages of A/Krasnodar/101/59 and B/Victoria/2/87 wild type strains at low temperatures. The resulting CA strains possessed TS and CA phenotypes and had a reduced ability to reproduce in mouse lungs and nasal turbinates. They displayed a high protective efficacy in experiments on mice. The two CA strains reproduced well in chick embryos and MDCK cell line without change of TS and CA markers. The CA A/Krasnodar/35 strain during passages at low temperature acquired 13 mutations in the 6 internal genes, 8 of those mutations led to amino acid changes. The CA B/Victoria/63 strain acquired 8 mutations in the internal genes, 6 of which led to amino acid changes. The intranasal vaccination of mice with the CA A/Krasnodar/35 strain led to a transitory suppression of various lymphocyte subpopulations, as well as to an increase in the number of some other cell types. The CA strains in question may be used in the future as attenuation donors for live influenza vaccines.
PubMed: 23785755
Affiliations:
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Le document en format XML
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Gendon</name></author><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name></author><author><name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name></author><author><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name></author><author><name sortKey="Akhmatova, N K" sort="Akhmatova, N K" uniqKey="Akhmatova N" first="N K" last="Akhmatova">N K Akhmatova</name></author><author><name sortKey="Koptiaeva, I B" sort="Koptiaeva, I B" uniqKey="Koptiaeva I" first="I B" last="Koptiaeva">I B Koptiaeva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2013 Jan-Feb</MedlineDate></PubDate></date><idno type="RBID">pubmed:23785755</idno><idno type="pmid">23785755</idno><idno type="wicri:Area/PubMed/Corpus">000121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000121</idno><idno type="wicri:Area/PubMed/Curation">000121</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000121</idno><idno type="wicri:Area/PubMed/Checkpoint">000591</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000591</idno><idno type="wicri:Area/Ncbi/Merge">000921</idno><idno type="wicri:Area/Ncbi/Curation">000921</idno><idno type="wicri:Area/Ncbi/Checkpoint">000921</idno><idno type="wicri:doubleKey">0507-4088::Gendon I:new:cold:adapted</idno><idno type="wicri:Area/Main/Merge">002F75</idno><idno type="wicri:Area/Main/Curation">002E00</idno><idno type="wicri:Area/Main/Exploration">002E00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[New cold-adapted donor strains for live influenza vaccine].</title><author><name sortKey="Gendon, Iu Z" sort="Gendon, Iu Z" uniqKey="Gendon I" first="Iu Z" last="Gendon">Iu Z. Gendon</name></author><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name></author><author><name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name></author><author><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name></author><author><name sortKey="Akhmatova, N K" sort="Akhmatova, N K" uniqKey="Akhmatova N" first="N K" last="Akhmatova">N K Akhmatova</name></author><author><name sortKey="Koptiaeva, I B" sort="Koptiaeva, I B" uniqKey="Koptiaeva I" first="I B" last="Koptiaeva">I B Koptiaeva</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term><term>Amino Acid Substitution</term><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Dogs</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (metabolism)</term><term>Influenza Vaccines (biosynthesis)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Mice</term><term>Mutation</term><term>Vaccines, Attenuated (biosynthesis)</term><term>Vaccines, Attenuated (genetics)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique (génétique)</term><term>Animaux</term><term>Basse température</term><term>Chiens</term><term>Embryon de poulet</term><term>Humains</term><term>Lignée cellulaire</term><term>Mutation</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (métabolisme)</term><term>Substitution d'acide aminé</term><term>Vaccins antigrippaux (biosynthèse)</term><term>Vaccins antigrippaux (génétique)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (biosynthèse)</term><term>Vaccins atténués (génétique)</term><term>Vaccins atténués (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adaptation physiologique</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Sous-type H2N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term><term>Animals</term><term>Cell Line</term><term>Chick Embryo</term><term>Cold Temperature</term><term>Dogs</term><term>Humans</term><term>Mice</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Chiens</term><term>Embryon de poulet</term><term>Humains</term><term>Lignée cellulaire</term><term>Mutation</term><term>Souris</term><term>Substitution d'acide aminé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cold-adapted (CA) strains A/Krasnodar/35 and B/Victoria/63 were isolated using passages of A/Krasnodar/101/59 and B/Victoria/2/87 wild type strains at low temperatures. The resulting CA strains possessed TS and CA phenotypes and had a reduced ability to reproduce in mouse lungs and nasal turbinates. They displayed a high protective efficacy in experiments on mice. The two CA strains reproduced well in chick embryos and MDCK cell line without change of TS and CA markers. The CA A/Krasnodar/35 strain during passages at low temperature acquired 13 mutations in the 6 internal genes, 8 of those mutations led to amino acid changes. The CA B/Victoria/63 strain acquired 8 mutations in the internal genes, 6 of which led to amino acid changes. The intranasal vaccination of mice with the CA A/Krasnodar/35 strain led to a transitory suppression of various lymphocyte subpopulations, as well as to an increase in the number of some other cell types. The CA strains in question may be used in the future as attenuation donors for live influenza vaccines.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Akhmatova, N K" sort="Akhmatova, N K" uniqKey="Akhmatova N" first="N K" last="Akhmatova">N K Akhmatova</name><name sortKey="Akopova, I I" sort="Akopova, I I" uniqKey="Akopova I" first="I I" last="Akopova">I I Akopova</name><name sortKey="Gendon, Iu Z" sort="Gendon, Iu Z" uniqKey="Gendon I" first="Iu Z" last="Gendon">Iu Z. Gendon</name><name sortKey="Koptiaeva, I B" sort="Koptiaeva, I B" uniqKey="Koptiaeva I" first="I B" last="Koptiaeva">I B Koptiaeva</name><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name><name sortKey="Tsfasman, T M" sort="Tsfasman, T M" uniqKey="Tsfasman T" first="T M" last="Tsfasman">T M Tsfasman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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